Arcanum: Of Steamworks and Magick Obscura Wiki
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From talking with the guard outside the isle of despair fort, you will learn that there is a sorcerous beast that has been threatening the locals. The guard will give you an amulet to dispose of it. Follow the shoreline until you find footprints and follow them back to its lair. The amulet increases you healing power with respect to poison but causes people to have a negative reaction to you.

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